Ethambutol

7

Summary

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Key Points

  • Ethambutol
    • Mechanism
      • Antitubercular
        • Used in combination with other antitubercular agents
    • Clinical Uses
      • Tuberculosis
        • Used as one of the 4-drug RIPE combination regimen for active tuberculosis: rifampin, isoniazid, pyrazinamide, and ethambutol
    • Side Effects and Adverse Reactions
      • Ocular (Eye) Toxicity
        • Can lead to optic neuritis, manifesting with blurred vision, loss of color (red-green) distinction, and decreased visual acuity
        • Reversed by discontinuation of the drug
        • Patient should receive frequent eye exams
      • Dizziness, confusion, hallucinations
      • Joint pain
      • **Note: other antitubercular drugs cause hepatotoxicity, but ethambutol does not