Serine

3763

Summary

Serine, which abbreviates to the 3-letters Ser or one-letter S, is one of the 20 amino acids that make up proteins in our body. Serine’s R-group is a hydroxymethyl group; that is, an alcohol attached to a single bridging carbon. Because of its hydroxyl group, serine can be phosphorylated; in fact, it is the amino acid most likely to be phosphorylated in our body. Serine is also a polar, hydrophilic amino acid, with a neutral charge at physiological pH.

Key Points

  • Serine
    • Abbreviations
      • Ser, S
    • Chemical Structure
    • R-Group: -CH2-OH
      • 1 bridging methylene β carbon (-CH2-)
        • Contrast vs. Threonine (which has a methyl substituent in place of one of the hydrogens on the β carbon)
      • Hydroxy group
        • Phosphorylatable by serine kinases
        • Serine is the amino acid most likely to be phosphorylated
    • Polarity
      • Polar (water soluble/hydrophilic)
    • Charge at pH 7
      • Neutral (0)