USMLE

Isoleucine

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Amino Acids
  1. Serine
  2. Asparagine
  3. Alanine
  4. Valine
  5. Leucine
  6. Isoleucine
  7. Phenylalanine
  8. Tryptophan
  9. Methionine
  10. Proline
  11. Glycine
  12. Threonine
  13. Cysteine
  14. Tyrosine
  15. Glutamine
  16. Aspartate
  17. Glutamate
  18. Histidine
  19. Lysine
  20. Arginine

Summary

Isoleucine, which is abbreviated as the 3-letters Ile or the single letter I, is one of the 20 amino acids that make up proteins in our body. Isoleucine’s R-group is a branched 4-carbon structure or sec-butyl group, with the carbons arranged in a cup or bowl-like structure. Since this R-group is non-polar, isoleucine is also a non-polar, hydrophobic amino acid, with a neutral charge at physiological pH.

Key Points

  • Isoleucine
    • Abbreviations
      • Ile, I
    • Chemical Structure
    • R-Group: Sec-butyl -CH(CH3)-CH2-CH3
    • Polarity
      • Non-polar (lipid soluble/hydrophobic)
    • Charge at pH 7
      • Neutral (0)