USMLE

Leucine

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Amino Acids
  1. Serine
  2. Asparagine
  3. Alanine
  4. Valine
  5. Leucine
  6. Isoleucine
  7. Phenylalanine
  8. Tryptophan
  9. Methionine
  10. Proline
  11. Glycine
  12. Threonine
  13. Cysteine
  14. Tyrosine
  15. Glutamine
  16. Aspartate
  17. Glutamate
  18. Histidine
  19. Lysine
  20. Arginine

Summary

Leucine, which abbreviates to the 3-letter Leu or single letter L, is one of the 20 amino acids that make up proteins in our body. Leucine’s R-group is an isobutyl group, which is just a branched, 4-carbon structure. Due to the non-polar nature of this R-group, leucine is also a non-polar, hydrophobic amino acid, with a neutral charge at physiological pH.

Key Points

  • Leucine
    • Abbreviations
      • Leu, L
    • Chemical Structure
    • R-group: Isobutyl -CH2-CH(CH3)2
    • Polarity
      • Non-polar (lipid soluble/hydrophobic)
    • Charge at pH 7
      • Neutral (0)