USMLE

NS3/4A Inhibitors

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Antivirals
  1. Oseltamivir, Zanamivir
  2. Acyclovir (Famciclovir, Valacyclovir)
  3. Ganciclovir
  4. Foscarnet
  5. Cidofovir
  6. NRTIs
  7. NNRTIs
  8. Integrase Inhibitors
  9. Protease Inhibitors
  10. Entry Inhibitors (Enfuvirtide, Maraviroc)
  11. NS5A Inhibitors
  12. NS5B Inhibitors
  13. NS3/4A Inhibitors

Summary

The NS3/4A inhibitors are drugs that end in -previr, including grazoprevir and simeprevir. These drugs are viral protease inhibitors that inhibit viral replication and are used to treat Hepatitis C.

Key Points

  • NS3/4A inhibitors
    • Drug Names (-previr ending)
      • Grazoprevir
      • Simeprevir
      • Glecaprevir
      • Paritaprevir
      • Voxilaprevir
    • Mechanism
      • Inhibits NS3/4A, a viral protease
        • Prevents viral replication
    • Clinical Use
      • Hepatitis C virus
    • Adverse Effects
      • Generally well-tolerated with non-specific side effects
      • Grazoprevir: headache, fatigue
      • Simeprevir: photosensitivity, rash