USMLE

NS5B Inhibitors

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Antivirals
  1. Oseltamivir, Zanamivir
  2. Acyclovir (Famciclovir, Valacyclovir)
  3. Ganciclovir
  4. Foscarnet
  5. Cidofovir
  6. NRTIs
  7. NNRTIs
  8. Integrase Inhibitors
  9. Protease Inhibitors
  10. Entry Inhibitors (Enfuvirtide, Maraviroc)
  11. NS5A Inhibitors
  12. NS5B Inhibitors
  13. NS3/4A Inhibitors

Summary

NS5B inhibitors share a common ending of -buvir, and include drugs such as sofosbuvir and dasabuvir. These drugs inhibit viral RNA-dependant RNA polymerase to prevent viral RNA replication. NS5B inhibitors treat Hepatitis C.

Key Points

  • NS5B inhibitors
    • Drug Names
      • Sofosbuvir
        • Nucleoside RNA polymerase inhibitor
      • Dasabuvir
        • Non-nucleoside RNA polymerase inhibitor
    • Mechanism
      • Inhibits viral RNA-dependent RNA polymerase (NS5B)
        • Causes RNA chain termination and prevents viral RNA replication
      • Requires intracellular activation
    • Clinical Use
      • Hepatitis C virus
    • Adverse Effects
      • Generally well-tolerated with non-specific side effects
      • Fatigue
        • Non-specific symptom; seen in 30-60% of patients
      • Headache
        • Seen in 20-40% of patients