USMLE

NS5A Inhibitors

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Antivirals
  1. Oseltamivir, Zanamivir
  2. Acyclovir (Famciclovir, Valacyclovir)
  3. Ganciclovir
  4. Foscarnet
  5. Cidofovir
  6. NRTIs
  7. NNRTIs
  8. Integrase Inhibitors
  9. Protease Inhibitors
  10. Entry Inhibitors (Enfuvirtide, Maraviroc)
  11. NS5A Inhibitors
  12. NS5B Inhibitors
  13. NS3/4A Inhibitors

Summary

NS5A inhibitors include the drugs that end is -asvir, such as ledipasvir. The exact mechanism of NS5A inhibitors is unknown, but they are thought to inhibit viral replication. These drugs are used to treat Hepatitis C infections.

Key Points

  • NS5A inhibitors
    • Drug Names (-asvir ending)
      • Ledipasvir
      • Ombitasvir
      • Velpatasvir
      • Elbasvir
      • Pibrentasvir
    • Mechanism
      • Inhibits viral phosphoprotein (NS5A)
        • Exact mechanism is unknown
        • Thought to disrupt viral RNA replication
    • Clinical Use
      • Hepatitis C virus
    • Adverse Effects
      • Generally well-tolerated with non-specific side effects
      • Headache
      • Diarrhea