5th Generation Cephalosporins

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Summary

Fifth generation cephalosporins are a class of antibiotics that includes the drug ceftaroline. While ceftaroline has broad spectrum coverage against gram-positive and gram-negative bacteria, it is generally clinically reserved as one of the only effective treatments against MRSA, or methicillin-resistant staph aureus.

Key Points

  • 5th Generation Cephalosporins
    • Drug Names
      • CefTAROLINE
    • Mechanism
      • Same as other Cephalosporins (see: Cephalosporin Overview)
    • Clinical Use
      • Broad gram positive and negative coverage
        • MRSA and E. faecalis
      • Does NOT cover Pseudomonas aeruginosa
    • Adverse Effects
      • Same as other Cephalosporins (see: Cephalosporin Overview)