2nd Generation Cephalosporins



Second generation cephalosporins are beta lactam antibiotics. There are four major drugs that are important to remember - cefoxitin, cefaclor, cefuroxime, and cefotetan. Like the first generation cephalosporins, second generation cephalosporins are highly effective against gram-positive cocci like staph and strep bacteria.

Key Points

  • 2nd Generation Cephalosporins
    • Drug Names
      • cefaCLOR
      • cefOXITIN
      • cefuROXIME
      • cefoTETAN
    • Mechanism
      • Same as other Cephalosporins (see: Cephalosporin Overview)
    • Clinical Use
      • Gram-positive cocci (e.g. Staph. spp., Strep. spp.)
        • Also used preoperatively for wound infection prophylaxis
      • Some gram-negative activity
        • H. influenzae
        • Enterobacter aerogenes
        • Neisseria
        • Serratia marcescens
        • Proteus mirabilis
        • E. Coli
        • Klebsiella pneumoniae
    • Adverse Effects
      • Same as other Cephalosporins (see: Cephalosporin Overview)