USMLE

2nd Generation Cephalosporins

1,546 views
Antibiotics / Antiparasitics
  1. Penicillin Overview
  2. Penicillinase-Sensitive vs. Penicillinase-Resistant Penicillins
  3. Anti-Pseudomonal Penicillins
  4. Cephalosporins Overview
  5. 1st Generation Cephalosporins
  6. 2nd Generation Cephalosporins
  7. 3rd Generation Cephalosporins
  8. 4th Generation Cephalosporins
  9. 5th Generation Cephalosporins
  10. Carbapenems
  11. Monobactams (Aztreonam)
  12. Vancomycin
  13. Aminoglycosides
  14. Tetracyclines
  15. Tigecycline
  16. Chloramphenicol
  17. Clindamycin
  18. Linezolid
  19. Macrolides
  20. Polymyxins
  21. Sulfonamides
  22. Dapsone
  23. Trimethoprim
  24. Fluoroquinolones
  25. Daptomycin
  26. Metronidazole
  27. Rifamycins (Rifampin, Rifabutin)
  28. Isoniazid
  29. Pyrazinamide
  30. Ethambutol
  31. Chloroquine

Summary

Second generation cephalosporins are beta lactam antibiotics. There are four major drugs that are important to remember - cefoxitin, cefaclor, cefuroxime, and cefotetan. Like the first generation cephalosporins, second generation cephalosporins are highly effective against gram-positive cocci like staph and strep bacteria.

Key Points

  • 2nd Generation Cephalosporins
    • Drug Names
      • cefaCLOR
      • cefOXITIN
      • cefuROXIME
      • cefoTETAN
    • Mechanism
      • Same as other Cephalosporins (see: Cephalosporin Overview)
    • Clinical Use
      • Gram-positive cocci (e.g. Staph. spp., Strep. spp.)
        • Also used preoperatively for wound infection prophylaxis
      • Some gram-negative activity
        • H. influenzae
        • Enterobacter aerogenes
        • Neisseria
        • Serratia marcescens
        • Proteus mirabilis
        • E. Coli
        • Klebsiella pneumoniae
    • Adverse Effects
      • Same as other Cephalosporins (see: Cephalosporin Overview)