USMLE

1st Generation Cephalosporins

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Antibiotics / Antiparasitics
  1. Penicillin Overview
  2. Penicillinase-Sensitive vs. Penicillinase-Resistant Penicillins
  3. Anti-Pseudomonal Penicillins
  4. Cephalosporins Overview
  5. 1st Generation Cephalosporins
  6. 2nd Generation Cephalosporins
  7. 3rd Generation Cephalosporins
  8. 4th Generation Cephalosporins
  9. 5th Generation Cephalosporins
  10. Carbapenems
  11. Monobactams (Aztreonam)
  12. Vancomycin
  13. Aminoglycosides
  14. Tetracyclines
  15. Tigecycline
  16. Chloramphenicol
  17. Clindamycin
  18. Linezolid
  19. Macrolides
  20. Polymyxins
  21. Sulfonamides
  22. Dapsone
  23. Trimethoprim
  24. Fluoroquinolones
  25. Daptomycin
  26. Metronidazole
  27. Rifamycins (Rifampin, Rifabutin)
  28. Isoniazid
  29. Pyrazinamide
  30. Ethambutol
  31. Chloroquine

Summary

First generation cephalosporins are beta lactam antibiotics.  There are two drug names of the first-generation cephalosporins that are important to remember: cefaZOLin and cephaLEXin. These antibiotics are active against gram-positive cocci like staph and strep bacteria. Because gram-positive cocci most commonly make up the skin flora, first generation cephalosporins are most often used for preoperative antibiotic prophylaxis, to prevent wound infections caused by skin bacteria.

Key Points

  • 1st Generation Cephalosporins
    • Drug Names
      • cefaZOLIN
      • cephaLEXIN
    • Mechanism
      • Same as other Cephalosporins (see: Cephalosporin Overview)
    • Clinical Use
      • Gram-positive cocci (e.g. Staph. spp., Strep spp.)
        • Used preoperatively to prevent wound infections by skin flora (e.g. S. aureus)
      • Proteus mirabilis
      • E. Coli
      • Klebsiella pneumoniae
    • Adverse Effects
      • Same as other Cephalosporins (see: Cephalosporin Overview)