USMLE

Anti-Pseudomonal Penicillins

1,813 views
Antibiotics / Antiparasitics
  1. Penicillin Overview
  2. Penicillinase-Sensitive vs. Penicillinase-Resistant Penicillins
  3. Anti-Pseudomonal Penicillins
  4. Cephalosporins Overview
  5. 1st Generation Cephalosporins
  6. 2nd Generation Cephalosporins
  7. 3rd Generation Cephalosporins
  8. 4th Generation Cephalosporins
  9. 5th Generation Cephalosporins
  10. Carbapenems
  11. Monobactams (Aztreonam)
  12. Vancomycin
  13. Aminoglycosides
  14. Tetracyclines
  15. Tigecycline
  16. Chloramphenicol
  17. Clindamycin
  18. Linezolid
  19. Macrolides
  20. Polymyxins
  21. Sulfonamides
  22. Dapsone
  23. Trimethoprim
  24. Fluoroquinolones
  25. Daptomycin
  26. Metronidazole
  27. Rifamycins (Rifampin, Rifabutin)
  28. Isoniazid
  29. Pyrazinamide
  30. Ethambutol
  31. Chloroquine

Summary

Antipseudomonal penicillins are a group of beta-lactam antibiotics that belong to the penicillin family. Two important drug names for the antipseudomonal penicillins are piperacillin and ticarcillin. These drugs share the same mechanism and many properties with other penicillins, but are notable for their extended coverage of gram-negative bacteria, especially Pseudomonas aeruginosa. The major method by which bacteria become resistant to antipseudomonal penicillins is by creating penicillinases or beta-lactamases.

Key Points

  • Antipseudomonal Penicillins
    • Drug Names
      • Piperacillin
      • Ticarcillin
      • Carbenicillin
    • Mechanism
      • Same as Penicillin
    • Clinical Use
      • Extended-spectrum coverage
        • Pseudomonas spp.
        • Other gram-negative rods
    • Adverse Effects
      • Same as Penicillin
    • Resistance
      • Sensitive to penicillinase (beta-lactamases)
        • Easily inactivated by cleavage of beta-lactam ring
        • Administer with beta-lactamase inhibitors (tazobactam)