Anti-Pseudomonal Penicillins
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Antibiotics / Antiparasitics
- Penicillin Overview
- Penicillinase-Sensitive vs. Penicillinase-Resistant Penicillins
- Anti-Pseudomonal Penicillins
- Cephalosporins Overview
- 1st Generation Cephalosporins
- 2nd Generation Cephalosporins
- 3rd Generation Cephalosporins
- 4th Generation Cephalosporins
- 5th Generation Cephalosporins
- Carbapenems
- Monobactams (Aztreonam)
- Vancomycin
- Aminoglycosides
- Tetracyclines
- Tigecycline
- Chloramphenicol
- Clindamycin
- Linezolid
- Macrolides
- Polymyxins
- Sulfonamides
- Dapsone
- Trimethoprim
- Fluoroquinolones
- Daptomycin
- Metronidazole
- Rifamycins (Rifampin, Rifabutin)
- Isoniazid
- Pyrazinamide
- Ethambutol
- Chloroquine
Summary
Antipseudomonal penicillins are a group of beta-lactam antibiotics that belong to the penicillin family. Two important drug names for the antipseudomonal penicillins are piperacillin and ticarcillin. These drugs share the same mechanism and many properties with other penicillins, but are notable for their extended coverage of gram-negative bacteria, especially Pseudomonas aeruginosa. The major method by which bacteria become resistant to antipseudomonal penicillins is by creating penicillinases or beta-lactamases.
Key Points
- Antipseudomonal Penicillins
- Drug Names
- Piperacillin
- Ticarcillin
- Carbenicillin
- Mechanism
- Same as Penicillin
- Clinical Use
- Extended-spectrum coverage
- Pseudomonas spp.
- Other gram-negative rods
- Extended-spectrum coverage
- Adverse Effects
- Same as Penicillin
- Resistance
- Sensitive to penicillinase (beta-lactamases)
- Easily inactivated by cleavage of beta-lactam ring
- Administer with beta-lactamase inhibitors (tazobactam)
- Sensitive to penicillinase (beta-lactamases)
- Drug Names