USMLE

Clopidogrel

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Cardiovascular Drugs
  1. Beta Blockers
  2. ACE Inhibitors
  3. Angiotensin II Receptor Blockers (ARBs)
  4. Adenosine
  5. Atropine
  6. Amiodarone
  7. DHP Calcium Channel Blockers
  8. Non-DHP Calcium Channel Blockers
  9. Clonidine
  10. Clopidogrel
  11. Digoxin
  12. Dopamine
  13. Epinephrine
  14. Hydralazine
  15. Loop Diuretics
  16. Nitroglycerin
  17. Norepinephrine
  18. Spironolactone
  19. Statins
  20. Thiazide Diuretics

Summary

Clopidogrel, also known by its trade name Plavix, is an antiplatelet drug that works to prevent the formation of blood clots. The prevention of clots is useful in preventing thrombotic diseases caused by clots like myocardial infarctions and strokes. Side effects of clopidogrel include bleeding and thrombocytopenia.

Key Points

  • Class and Mechanism
    • Antiplatelet
      • Inhibits platelet aggregation and prevents ADP from binding with the ADP receptor
      • Prevents clot formation
    • Clinical Use
      •  Thromboembolism prophylaxis
        • Myocardial infarction (MI)
        • Stroke
    • Side Effects and Adverse Reactions
      • Bleeding
        • discontinue 7 days before surgery
        • Due to inhibition of platelet function and potential thrombocytopenia (low platelet count)
        • Contraindicated in patients with any active bleeding, peptic ulcers, etc.
        • Carefully monitor for any signs/symptoms of bleeding
      • Hypotension
      • GI effects
        • Diarrhea, dyspepsia, abdominal pain