Medicine & USMLE


Hematology Drugs
  1. Dabigatran / Argatroban
  2. Factor Xa Inhibitors (Rivaroxaban, Apixaban)
  3. Heparin
  4. Low Molecular Weight Heparins (Enoxaparin, Fondaparinux, Dalteparin)
  5. Warfarin
  6. Aspirin
  7. GPIIb/IIIa Inhibitors (Abciximab, Tirofiban, Eptifibatide)
  8. Clopidogrel
  9. Alteplase / tPA
  10. Iron
  11. Filgrastim
  12. Epoetin Alfa


Clopidogrel, also known by its trade name Plavix, is an antiplatelet drug that works to prevent the formation of blood clots. The prevention of clots is useful in preventing thrombotic diseases caused by clots like myocardial infarctions and strokes. Side effects of clopidogrel include bleeding and thrombocytopenia.

Key Points

  • Class and Mechanism
    • Antiplatelet
      • Inhibits platelet aggregation and prevents ADP from binding with the ADP receptor
      • Prevents clot formation
    • Clinical Use
      •  Thromboembolism prophylaxis
        • Myocardial infarction (MI)
        • Stroke
    • Side Effects and Adverse Reactions
      • Bleeding
        • discontinue 7 days before surgery
        • Due to inhibition of platelet function and potential thrombocytopenia (low platelet count)
        • Contraindicated in patients with any active bleeding, peptic ulcers, etc.
        • Carefully monitor for any signs/symptoms of bleeding
      • Hypotension
      • GI effects
        • Diarrhea, dyspepsia, abdominal pain