Clopidogrel
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Hematology Drugs
- Dabigatran / Argatroban
- Factor Xa Inhibitors (Rivaroxaban, Apixaban)
- Heparin
- Low Molecular Weight Heparins (Enoxaparin, Fondaparinux, Dalteparin)
- Warfarin
- Aspirin
- GPIIb/IIIa Inhibitors (Abciximab, Tirofiban, Eptifibatide)
- Clopidogrel
- Alteplase / tPA
- Iron
- Filgrastim
- Epoetin Alfa
Summary
Clopidogrel, also known by its trade name Plavix, is an antiplatelet drug that works to prevent the formation of blood clots. The prevention of clots is useful in preventing thrombotic diseases caused by clots like myocardial infarctions and strokes. Side effects of clopidogrel include bleeding and thrombocytopenia.
Key Points
- Class and Mechanism
- Antiplatelet
- Inhibits platelet aggregation and prevents ADP from binding with the ADP receptor
- Prevents clot formation
- Clinical Use
- Thromboembolism prophylaxis
- Myocardial infarction (MI)
- Stroke
- Thromboembolism prophylaxis
- Side Effects and Adverse Reactions
- Bleeding
- discontinue 7 days before surgery
- Due to inhibition of platelet function and potential thrombocytopenia (low platelet count)
- Contraindicated in patients with any active bleeding, peptic ulcers, etc.
- Carefully monitor for any signs/symptoms of bleeding
- Hypotension
- GI effects
- Diarrhea, dyspepsia, abdominal pain
- Bleeding
- Antiplatelet