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Key Points

  • Drug Names
    • Lovastatin, Simvastatin, Rosuvastatin, Atorvastatin, Pravastatin
    • Mechanism
      • Antihyperlipidemic
        • Inhibits HMG-CoA reductase, an early component in cholesterol biosynthesis
        • Most of the cholesterol in the body is synthesized during the fasting state at night.
          • Should be taken in the evening
    • Clinical use
      • Hypercholesterolemia
        • Reduces LDL, VLDL cholesterol
        • Raises HDL cholesterol
      • Coronary Artery Disease
        • Risk reduction for myocardial infarction, stroke, atherosclerosis
    • Side Effects and Adverse Reactions
      • Myopathy
        • Generalized muscle pain/weakness
        • Can turn into rhabdomyolysis
        • Monitor CK levels while on treatment
      • Hepatotoxicity
        • Monitor liver enzymes
      • May be Teratogenic
        • Pregnancy Risk Category X
      • Abrupt discontinuation can cause rebound hypercholesterolemia and myocardial infarction