Tizanidine
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Sympathomimetics and Sympatholytics (Old)
- Dopamine
- Fenoldopam
- Dobutamine
- Epinephrine
- Norepinephrine
- Isoproterenol
- Midodrine
- Phenylephrine and Pseudoephedrine
- (Alpha) Methyldopa
- Clonidine (and Guanfacine)
- Tizanidine
Summary
Tizanidine is an alpha-2 activating drug used to treat muscle spasms in a variety of conditions. Side effects of tizanidine include hypotension.
Key Points
- Tizanidine
- Mechanism
- Centrally-acting alpha-2 receptor agonist
- Related to clonidine, but less effective on modulating sympathetic outflow to heart and blood vessels
- Centrally-acting alpha-2 receptor agonist
- Indications
- Muscle spasticity (antispasmodic)
- Mechanism for relief is unclear
- e.g. Multiple sclerosis, ALS, Cerebral Palsy
- Muscle spasticity (antispasmodic)
- Side Effects
- Hypotension
- Mechanism
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