Tizanidine

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Summary

Tizanidine is an alpha-2 activating drug used to treat muscle spasms in a variety of conditions. Side effects of tizanidine include hypotension.

Key Points

  • Tizanidine
    • Mechanism
      • Centrally-acting alpha-2 receptor agonist
        • Related to clonidine, but less effective on modulating sympathetic outflow to heart and blood vessels
    • Indications
      • Muscle spasticity (antispasmodic)
        • Mechanism for relief is unclear
        • e.g. Multiple sclerosis, ALS, Cerebral Palsy
    • Side Effects
      • Hypotension