USMLE

Pramipexole, Ropinirole

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Other Neuro Pharm
  1. Ramelteon
  2. Triptans
  3. Benzodiazepines - Function
  4. Zolpidem Zaleplon Eszopiclone
  5. Suvorexant
  6. Bromocriptine (Ergot Dopamine Agonists)
  7. Pramipexole, Ropinirole
  8. Amantadine
  9. Levodopa, Carbidopa
  10. Entacapone, Tolcapone
  11. Selegiline and Rasagiline
  12. Benztropine, Trihexyphenidyl
  13. Tetrabenazine
  14. Baclofen
  15. Memantine
  16. Riluzole
  17. Full Opioid Agonists
  18. Partial Opioid Agonists
  19. Dextromethorphan
  20. Tramadol
  21. Naloxone
  22. Naltrexone

Summary

Pramipexole and Ropinirole are drugs that work by activating dopamine receptors to mimic endogenous dopamine activity. This activating effect at dopamine receptors then helps increase motor control of body movements, which is helpful in treating Parkinson’s disease and Restless Leg Syndrome. A major adverse effect of Pramipexole and Ropinirole is impulse control disorder. Other adverse side effects of Pramipexole and Ropinirole include hallucinations, confusion, and hypotension.

Key Points

  • Pramipexole, ropinirole 
    • Mechanism
      • Non-ergot dopamine agonist
    • Clinical Use
      • Parkinson disease
        • Delays need for using levodopa in Parkinsons
      • Restless leg syndrome
    • Adverse effects
      • Impulse control disorder
      • Hallucinations
      • Postural hypotension
      • Confusion