Benztropine, Trihexyphenidyl
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Benztropine, Trihexyphenidyl
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Summary
Benztropine and Trihexyphenidyl are drugs used to treat Parkinson's disease and drug-induced Parkinsonism. They work by functioning as anticholinergic medications. Specifically, anticholinergic drugs help improve tremor and rigidity seen in Parkison’s disease and drug-induced parkinsonism. Given their mechanism, it should also make sense that benztropine and trihexyphenidyl can cause anticholinergic symptoms.
Key Points
- Benztropine, Trihexyphenidyl
- Mechanism
- Act as Anticholinergic
- Clinical Use
- Treat tremor in Parkinson’s disease
- Improve tremor and rigidity but have little effect on bradykinesia in Parkinson disease
- Under normal conditions, dopamine and acetylcholine are in electrochemical balance in the basal ganglia
- Decreased dopamine in Parkinson's disease (PD) leads to increased cholinergic sensitivity.
- Drug-induced parkinsonism (1st line)
- Treat tremor in Parkinson’s disease
- Adverse Effects:
- Anticholinergic side effects
- Mechanism