Vortioxetine is a drug used to treat major depressive disorder. It works to increase serotonin signaling, primarily by inhibiting the reuptake of serotonin at neuronal synapses. This increase in serotonin is obviously useful in treating psychiatric disorders like major depression. An important side effect to remember is serotonin syndrome, which is more common if vortioxetine is given along with other serotonin-modulating drugs. Other side effects of vortioxetine can include nausea, sleep disturbances, and anticholinergic effects.