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Pharmacology

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Antiepileptics

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Topiramate

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Summary

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Key Points

  • Topiramate
    • Mechanism
      • Blocks Na+ channels
        • Blocking of sodium ion influx inhibitors depolarization of neuron, inhibiting firing of AP
      • Increases GABA action
      • Also blocks Ca2+ channels
    • Clinical Use
      • Broad-spectrum antiepileptic
        • Used to treat focal (partial) and generalized (tonic-clonic) seizures
      • Migraine prophylaxis
    • Adverse Effects
      • Kidney stones
      • Sedation, slow cognition (word-finding difficulties), weight loss, glaucoma (rare)