USMLE

TNF Inhibitors (Infliximab, Adalimumab. Certolizumab, Golimumab)

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Musculoskeletal Pharm
  1. Aspirin
  2. Acetaminophen
  3. N-Acetylcysteine (NAC)
  4. Celecoxib
  5. NSAIDs
  6. Leflunomide
  7. Bisphosphonates
  8. Teriparatide
  9. Cyclobenzaprine
  10. Dantrolene
  11. Etanercept
  12. TNF Inhibitors (Infliximab, Adalimumab. Certolizumab, Golimumab)
  13. Allopurinol/Febuxostat
  14. Probenecid
  15. Colchicine
  16. Rasburicase

Summary

Infliximab, adalimumab, certolizumab, golimumab are monoclonal antibodies against TNF-alpha. They work by blocking TNF-alpha’s effects in the body, suppressing inflammation and damage caused by autoimmune diseases. Clinically these drugs are used to treat autoinflammatory conditions like IBD, psoriasis, ankylosing spondylitis, and others. Side effects of these drugs include GI upset, serum sickness, and immunosuppression.