USMLE

Etanercept

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Musculoskeletal Pharm
  1. Aspirin
  2. Acetaminophen
  3. N-Acetylcysteine (NAC)
  4. Celecoxib
  5. NSAIDs
  6. Leflunomide
  7. Bisphosphonates
  8. Teriparatide
  9. Cyclobenzaprine
  10. Dantrolene
  11. Etanercept
  12. TNF Inhibitors (Infliximab, Adalimumab. Certolizumab, Golimumab)
  13. Allopurinol/Febuxostat
  14. Probenecid
  15. Colchicine
  16. Rasburicase

Summary

Etanercept is an anti-inflammatory drug used to treat rheumatoid arthritis and other inflammatory conditions. Etanercept works by inhibiting TNF signaling, by acting as a decoy receptor for TNF. The resulting decrease in TNF signaling has potent anti-inflammatory effects. Clinically, etanercept is used to treat autoimmune diseases like rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Since etanercept is immunosuppressive, it comes with a risk of reactivating latent TB.

Key Points

  • Etanercept
    • Mechanism
      • Acts as Anti-TNFagent
        •  Intercepts TNF to prevent it from inducing inflammation
    • Clinical Use
      • Treats Autoimmune inflammatory conditions (arthritis)
        • Rheumatoid Arthritis
        • Psoriasis
        • Psoriatic arthritis
        • Ankylosing spondylitis
    • Adverse Effects
      • Causes reactivation of latent TB
        • TNF-α plays a key role in granuloma formation and stabilization
        • Prior to beginning therapy, patients should be screened for latent tuberculosis in order to avoid reactivation/dissemination
      • Causes SLE-like Syndrome
      • Causes Immunosuppression
        • Increased risk of infections
        • Increased risk of lymphomas