Cyclobenzaprine is an antispasmodic drug used to treat muscle spasms and other involuntary muscle contractions. Its exact mechanism is unclear, but it is known to act centrally on the brainstem and spinal cord to inhibit motor neurons. Cyclobenzaprine is notably an anticholinergic drug, and its use may be associated with anticholinergic side effects.

Key Points

  • Cyclobenzaprine
    • Mechanism
      • Poorly understood
        • Structurally related to TCAs
      • Acts as centrally acting/CNS
    • Clinical Use
      • Treats muscle spasms (antispasmodic)
    • Adverse effects
      • Anticholinergic
      • Causes Heart block
      • Contraindicated with MAOIs