Mycosis Fungoides / Sezary Syndrome

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Summary

Mycosis Fungoides and Sezary Syndromes are T-cell cancers caused by invading atypical helper or CD4-positive T-cells.

Mycosis Fungoides is characterized by skin lesions like skin plaques or tumors due to cutaneous invasion by cancerous helper T-Cells. Skin biopsies of these lesions will show atypical T-cells with cerebriform nuclei and epidermal Pautrier’s microabscesses. When these atypical T-cells spread to lymph nodes or to the bloodstream, the disease is called Sezary syndrome.