USMLE

Mycosis Fungoides / Sezary Syndrome

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Leukemias and Lymphomas
  1. Acute Myelogenous Leukemia (AML)
  2. Acute Promyelocytic Leukemia (APL)
  3. Acute Lymphocytic Leukemia (ALL)
  4. Chronic Myelogenous Leukemia (CML)
  5. Chronic Lymphocytic Leukemia (CLL)
  6. Hairy Cell Leukemia (HCL)
  7. Hodgkin Lymphoma
  8. Burkitt Lymphoma
  9. Diffuse Large B Cell Lymphoma (DLBCL)
  10. Follicular Lymphoma
  11. Mantle Cell Lymphoma
  12. Marginal Zone Lymphoma
  13. Primary CNS Lymphoma (PCNSL)
  14. Acute T-Cell Leukemia/Lymphoma (ATLL)
  15. Mycosis Fungoides / Sezary Syndrome

Summary

Mycosis Fungoides and Sezary Syndromes are T-cell cancers caused by invading atypical helper or CD4-positive T-cells.

Mycosis Fungoides is characterized by skin lesions like skin plaques or tumors due to cutaneous invasion by cancerous helper T-Cells. Skin biopsies of these lesions will show atypical T-cells with cerebriform nuclei and epidermal Pautrier’s microabscesses. When these atypical T-cells spread to lymph nodes or to the bloodstream, the disease is called Sezary syndrome.