Medicine & USMLE


Other Neuro Pharm
  1. Ramelteon
  2. Triptans
  3. Benzodiazepines - Function
  4. Zolpidem Zaleplon Eszopiclone
  5. Suvorexant
  6. Bromocriptine (Ergot Dopamine Agonists)
  7. Pramipexole, Ropinirole
  8. Amantadine
  9. Levodopa, Carbidopa
  10. Entacapone, Tolcapone
  11. Selegiline and Rasagiline
  12. Benztropine, Trihexyphenidyl
  13. Tetrabenazine
  14. Baclofen
  15. Memantine
  16. Riluzole
  17. Full Opioid Agonists
  18. Partial Opioid Agonists
  19. Dextromethorphan
  20. Tramadol
  21. Naloxone
  22. Naltrexone


Ramelteon is a drug used to promote sleep. It is an agonist of melatonin receptors in the suprachiasmatic nucleus of the hypothalamus. By inducing sleep, ramelteon is useful as a hypnotic for the treatment of insomnia. There’s a few nonspecific side effects of ramelteon, including dizziness, nausea, fatigue, and headaches. Finally, ramelteon does not cause dependence so it's generally safer to use compared to other sleep-promoting drugs like the benzodiazepines!

Key Points

  • Ramelteon
    • Mechanism
      • Melatonin receptor agonist (hence the mel in the name)
        • Binds MT1 and MT2 in suprachiasmatic nucleus
    • Clinical Use
      • Treats Insomnia
    • Adverse effects
      • Dizziness
      • Nausea
      • Fatigue
      • Headache
      • No dependence (not a controlled substance)