Previous
Next

Filovirus

11
Watch Video

Summary

Coming soon...

Key Points

  • Filoviruses
    • Characteristics
      • RNA viruses
        • replicate in the cytoplasm of cells
        • Single-stranded
        • - sense
        • Linear
      • Enveloped
      • Helical capsid
    • Presentation
      • Ebolaviruses
        • Transmission
          • Travel to endemic countries
            • direct contact with bodily fluids, fomites (including dead bodies), infected bats or primates (apes/monkeys)
          • high incidence of nosocomial (health-care related) infection
        • Pathogenesis
          • Targets endothelial cells, hepatocytes, phagocytes
        • Presentation
          • incubation period of up to 21 days
          • abrupt onset of flu-like symptoms (high fever, myalgia), diarrhea, and vomiting
          • DIC, diffuse hemorrhage, shock, conjunctival injection
        • Diagnosis
          • RT-PCR
            • Viral RNA detectable within 48 hrs of sxs onset
        • Treatment
          • Supportive ; no definitive treatment
            • High mortality rate
          • Strict isolation for infected individuals and barrier practices for health care workers are key in preventing transmission
      • Marburg hemorrhagic fever