Paramyxovirus
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Key Points
- Paramyxoviruses
- Characteristics
- RNA viruses
- replicate in the cytoplasm of cells
- Single-stranded
- - sense
- Linear chromosome
- Nonsegmented
- Enveloped
- Obtained by budding through plasma membrane of host cell
- Helical capsid
- Viral membrane contains antigens
- Hemagglutinin
- Binds sialic acid and promotes viral entry
- Neuraminidase
- Promotes progeny virion release
- Matrix protein
- Used for viral assembly
- F (fusion) protein
- Responsible for fusion of viral membrane with host cell, releasing nucleocapsid core into the target cell
- Can also induce cell-cell fusion of membranes in respiratory epithelia, forming multinucleated cells
- Hemagglutinin
- RNA viruses
- Characteristics