USMLE

Paramyxovirus

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Viruses - RNA Viruses
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Key Points

  • Paramyxoviruses
    • Characteristics
      • RNA viruses
        • replicate in the cytoplasm of cells
        • Single-stranded
      • - sense
      • Linear chromosome
      • Nonsegmented
      • Enveloped
        • Obtained by budding through plasma membrane of host cell
      • Helical capsid
      • Viral membrane contains antigens
        • Hemagglutinin
          • Binds sialic acid and promotes viral entry
        • Neuraminidase
          • Promotes progeny virion release
        • Matrix protein
          • Used for viral assembly
        • F (fusion) protein
          • Responsible for fusion of viral membrane with host cell, releasing nucleocapsid core into the target cell
          • Can also induce cell-cell fusion of membranes in respiratory epithelia, forming multinucleated cells