Hepevirus (Hepatitis E Virus)
4,411 views
Viruses - RNA Viruses
- HIV: Microbiology and Characteristics
- HIV: Clinical Course
- Reovirus
- Picornavirus Overview
- Poliovirus
- Echovirus
- Rhinovirus
- Coxsackievirus
- Hepatitis A Virus (HAV)
- Hepevirus (Hepatitis E Virus)
- Calicivirus
- Flavivirus
- Hepatitis C Virus (HCV)
- Yellow Fever Virus
- Dengue Virus
- St. Louis Encephalitis and West Nile Virus
- Zika Virus
- Togavirus
- Rubella
- Retrovirus
- Coronavirus
- Orthomyxovirus
- Paramyxovirus
- Respiratory Syncytial Virus (RSV)
- Parainfluenza Virus (Croup)
- Measles
- Mumps
- Rhabdovirus
- Filovirus
- Arenavirus
- Bunyavirus
- Deltavirus
Key Points
- Hepeviruses (FA 2019 p167, MB)
- Characteristics
- RNA viruses
- replicate in the cytoplasm of cells
- Single-stranded
- + sense
- Linear chromosome
- No envelope
- Are not destroyed by the gut
- Icosahedral capsid
- RNA viruses
- Presentation and Key Viruses
- Hepatitis E virus (HEV)
- Transmission
- Fecal-oral (esp. waterborne)
- Enteric, epidemic (e.g. in parts of Asia, sub-Saharan Africa, Middle East, Mexico)
- No carrier state
- Presentation
- Acute hepatitis
- Occurs after short incubation period (5-6 weeks)
- Fever, jaundice, elevated ALT and AST
- Usually mild and self-limiting in adults
- Fulminant hepatitis in pregnant women
- High mortality in pregnancy
- Acute hepatitis
- Diagnosis
- Liver Biopsy
- All viral hepatitis produce a similar histopathological pattern
- Hepatocyte swelling (necrosis)
- “Ballooning degeneration”, thought to be caused by ATP depletion and disruption of cytoskeleton
- Hyperplasia may also occur due to regeneration of tissue (active cell replication) lost to viral damage
- Monocyte infiltration
- Occurs due to viral infection and hepatocyte necrosis
- Councilman bodies
- Apoptotic bodies form round pink (eosinophilic) bodies known as Councilman bodies
- HEVAg can be detected by ELISA, or HEV RNA by RT-PCR
- Anti-HEV antibodies may be seen in blood
- Liver Biopsy
- Treatment
- Supportive
- Transmission
- Hepatitis E virus (HEV)
- Characteristics