Polyomavirus
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Viruses - DNA Viruses
- Herpesvirus Overview
- Herpes Simplex Virus 1 (HSV1)
- Herpes Simplex Virus 2 (HSV2)
- Varicella-Zoster Virus (HHV3)
- Epstein-Barr Virus (HHV4)
- Cytomegalovirus (HHV5)
- Human Herpesviruses 6 and 7 (HHV6 and HHV7)
- Human Herpesviruses 8 (HHV8)
- Poxvirus
- Hepadnavirus
- Adenovirus
- Papillomavirus (HPV)
- Polyomavirus
- Parvovirus
Key Points
- Polyomavirus
- Characteristics
- DNA virus
- Replicates in nucleus
- Double-stranded
- No envelope
- Circular chromosome
- DNA virus
- Transmission
- Not well understood
- Oral or respiratory transmission is thought to be the main mode
- Not well understood
- Presentation
- Causes disease in immunocompromised patients
- e.g. HIV/AIDS, lymphoma, leukemia, etc.
- JC virus (John Cunningham)
- Progressive multifocal leukoencephalopathy (PML)
- Demyelinating disease
- Presents with focal neurological deficits, dementia, visual defects
- Preferentially affects oligodendrocytes
- Demyelinating disease
- Progressive multifocal leukoencephalopathy (PML)
- BK virus
- Seen in transplant patients
- e.g. kidney transplant, or hematopoietic stem cell transplant
- Kidney injury
- Nephropathy, ureteral stenosis, or hemorrhagic cystitis
- Elevated creatinine is seen
- Seen in transplant patients
- Causes disease in immunocompromised patients
- Diagnosis
- PCR is used
- Biopsy may show intranuclear inclusion bodies in infected tissue
- Treatment
- Supportive care; PML is often fatal
- Antiretroviral therapy for people with HIV/AIDS
- Characteristics