Poxvirus
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Viruses - DNA Viruses
- Herpesvirus Overview
- Herpes Simplex Virus 1 (HSV1)
- Herpes Simplex Virus 2 (HSV2)
- Varicella-Zoster Virus (HHV3)
- Epstein-Barr Virus (HHV4)
- Cytomegalovirus (HHV5)
- Human Herpesviruses 6 and 7 (HHV6 and HHV7)
- Human Herpesviruses 8 (HHV8)
- Poxvirus
- Hepadnavirus
- Adenovirus
- Papillomavirus (HPV)
- Polyomavirus
- Parvovirus
Key Points
- Poxvirus
- Key Viruses
- Molluscum contagiosum
- Smallpox (variola)
- eradicated world-wide by live attenuated vaccine
- Cowpox - milkmaid blisters
- Characteristics
- DNA virus
- Replicates in cytoplasm
- Carries its own DNA-dependent RNA polymerase
- Only DNA virus to not replicate in nucleus
- Double stranded
- Linear chromosome
- Largest DNA virus
- Replicates in cytoplasm
- Enveloped
- DNA virus
- Transmission
- Skin-to-skin contact
- May be transmitted by sexual contact, shared bath towels, contact sports
- Skin-to-skin contact
- Presentation: Molluscum
- Dome-shaped pearly papule with central umbilication
- Affects immunocompetent children or immunocompromised adults
- Often seen in HIV in adults (30% of patients)
- Aging thought to confer immunity
- Diagnosis
- Molluscum bodies seen on biopsy of lesion
- Large keratinocytes with granular eosinophilic cytoplasmic inclusions
- contains accumulated virions
- Large keratinocytes with granular eosinophilic cytoplasmic inclusions
- Molluscum bodies seen on biopsy of lesion
- Treatment
- Usually not indicated; disease is self-limiting
- Key Viruses