Baclofen is an anti-spasmodic agent used to treat a variety of muscle spasms or contractile disorders including cramps, and dystonias, as well as the muscle spasticity caused by multiple sclerosis or spinal cord injury. Its exact mechanism of action is unclear, but is thought to be related to agonism at GABA receptors in the spinal cord.

Key Points

  • Baclofen
    • Mechanism
      • Antispasmodic
        • GABAB receptor agonist in spinal cord
    • Clinical Use
      • Muscle spasticity
        • Dystonia
        • Multiple sclerosis
    • Adverse effects
      • CNS depression, respiratory depression
        • Mediated by GABA = inhibitory