USMLE

Baclofen

2,064 views
Other Neuro Pharm
  1. Ramelteon
  2. Triptans
  3. Benzodiazepines - Function
  4. Zolpidem Zaleplon Eszopiclone
  5. Suvorexant
  6. Bromocriptine (Ergot Dopamine Agonists)
  7. Pramipexole, Ropinirole
  8. Amantadine
  9. Levodopa, Carbidopa
  10. Entacapone, Tolcapone
  11. Selegiline and Rasagiline
  12. Benztropine, Trihexyphenidyl
  13. Tetrabenazine
  14. Baclofen
  15. Memantine
  16. Riluzole
  17. Full Opioid Agonists
  18. Partial Opioid Agonists
  19. Dextromethorphan
  20. Tramadol
  21. Naloxone
  22. Naltrexone

Summary

Baclofen is an anti-spasmodic agent used to treat a variety of muscle spasms or contractile disorders including cramps, and dystonias, as well as the muscle spasticity caused by multiple sclerosis or spinal cord injury. Its exact mechanism of action is unclear, but is thought to be related to agonism at GABA receptors in the spinal cord.

Key Points

  • Baclofen
    • Mechanism
      • Antispasmodic
        • GABAB receptor agonist in spinal cord
    • Clinical Use
      • Muscle spasticity
        • Dystonia
        • Multiple sclerosis
    • Adverse effects
      • CNS depression, respiratory depression
        • Mediated by GABA = inhibitory