Zileuton
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Respiratory Pharm
- Ipratropium vs Tiotropium
- 1st Generation Antihistamines
- 2nd-Generation Antihistamines
- Albuterol vs Salmeterol
- Fluticasone & Budesonide
- Montelukast & Zafirlukast
- Zileuton
- Omalizumab
- Cromolyn & Nedocromil
- Guaifenesin
- Endothelin Receptor Antagonists (Bosentan)
- Prostaglandin Analogs (Epoprostenol, Iloprost)
- Theophylline
Summary
Zileuton is an antiinflammatory drug sometimes used to treat asthma. It works by blocking the enzyme 5-LOX, which reduces the production of leukotrienes from arachidonic acid. This leukotriene reduction is helpful in preventing exacerbations in patients with asthma - also known as asthma attacks. One side effect of zileuton to know is hepatotoxicity.
Key Points
- Zileuton
- Mechanism
- Decreased production of leukotrienes
- Inhibits 5-lipoxygenase (5-LOX), thereby blocking the conversion of arachidonic acid to inflammatory leukotrienes.
- LTC4, LTD4, LTE4 cause bronchoconstriction. By inhibiting their formation, zileuton can prevent asthma episodes.
- Leukotrienes are synthesized from arachidonic acid via the lipoxygenase pathway. Zileuton inhibits this pathway, thus reducing leukotriene production.
- Inhibits 5-lipoxygenase (5-LOX), thereby blocking the conversion of arachidonic acid to inflammatory leukotrienes.
- Decreased production of leukotrienes
- Clinical indications
- Asthma
- Zileuton is used as a prophylactic therapy for asthma.
- Lipoxygenase inhibitors (eg, zileuton) decrease production of pro-inflammatory leukotrienes and are indicated for treatment of asthma
- Asthma
- Adverse effects
- Hepatotoxicity
- Mechanism