USMLE

Guaifenesin

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Respiratory Pharm
  1. Ipratropium vs Tiotropium
  2. 1st Generation Antihistamines
  3. 2nd-Generation Antihistamines
  4. Albuterol vs Salmeterol
  5. Fluticasone & Budesonide
  6. Montelukast & Zafirlukast
  7. Zileuton
  8. Omalizumab
  9. Cromolyn & Nedocromil
  10. Guaifenesin
  11. Endothelin Receptor Antagonists (Bosentan)
  12. Prostaglandin Analogs (Epoprostenol, Iloprost)
  13. Theophylline

Summary

Guaifenesin is a drug used to treat nasal congestion and productive cough. It acts as an expectorant to thin airway mucus secretions. While guaifenesin reduces mucus load and can therefore be used to treat productive or wet cough, it does not directly suppress the cough itself.

Key Points

  • Guaifenesin
    • Mechanism
      • Thins airway mucus (expectorant)
      • Improves patient’s ability to cough out or “expectorate” phlegm blocking airways
      • Does not suppress cough
    • Indications
      • Management of a productive (“wet”) cough
        • Can be taken acutely or chronically