USMLE Step 1

/

Pharmacology

/

Reproductive Pharm

Previous
Next

Anastrozole

426
Watch Video

Summary

Coming soon...

Key Points

  • Aromatase Inhibitors
    • Drug Names
      • Anastrozole
      • Letrozole
      • Exemestane
    • Mechanism
      • Aromatase inhibitor
        • Blocks estrogen production 
        • Aromatase converts testosterone to estradiol (estrogen), in a process known as aromatization
    • Clinical Use
      • ER+ breast cancer in postmenopausal women
        • ER+ breast cancer is dependent on estrogen for growth, and reduction of estrogen levels can improve prognosis
      • Infertility
      • Endometriosis
      • Leiomyoma
    • Adverse Effects
      • Osteoporosis
        • Suppression of estrogen production cause reduction of bone density, which is dependent on estrogen levels in women