Luteinizing Hormone (LH)

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Summary

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Key Points

  • Luteinizing Hormone (LH)
    • Type: Peptide
    • Origin: Anterior Pituitary
    • Trigger: Stimulation by GnRH from hypothalamus
      • GnRH = Gonadotropin Releasing Hormone
    • Target: Testes and Ovaries
      • Effect: Stimulates release of
        • Testosterone from testes
        • Estradiol/Estrogen from ovaries
        • Testosterone and Estradiol are androgens involved in reproduction as well as the development of secondary sex characteristics (i.e. body hair, breast and genital growth, etc)
    • Feedback:
      • Estradiol usually inhibits LH release through negative feedback
      • Exception: Luteal Surge
        • During ovulation, Estradiol increases LH release through positive feedback
          • This causes spikes in both Estradiol and LH, which in turn causes ovulation.