Hyoscyamine & Dicyclomine

1363

Summary

Hyoscyamine and dicyclomine are muscarinic antagonist drugs that antagonize the M3 muscarinic receptors in the GI tract, reducing GI motility and spasms. They are commonly used to treat irritable bowel syndrome.

Key Points

  • Hyoscyamine and Dicyclomine
    • Mechanism
      • Muscarinic antagonist
    • Clinical Use
      • Irritable Bowel Syndrome (antispasmodic)
        • Anticholinergic action at M3 receptors prevents contraction of smooth muscle along GI tract