Aprepitant is an antiemetic drug used to prevent nausea and vomiting induced by chemotherapy and anesthesia. Aprepitant functions by blocking substance P from binding to the NK1 receptor in vomiting centers of the brainstem.

Key Points

  • Aprepitant
    • Mechanism:
      • Blocks NK1 (neurokinin-1) receptors in brain
        • Substance P antagonist
    • Clinical Use:
      • Antiemetic for chemotherapy-induced nausea and vomiting
    • Adverse Effects:
      • Moderate inhibitor of CYP3A4
      • Headache
      • Constipation