Aprepitant
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Gastrointestinal Pharm
- H2 Blockers (Cimetidine, Ranitidine, Famotidine)
- Proton Pump Inhibitors (PPIs)
- Misoprostol
- Orlistat
- Antacids
- Bismuth & Sucralfate
- Octreotide
- Diphenoxylate vs. Loperamide
- Ondansetron
- Metoclopramide
- Bulk-forming Laxatives
- Senna
- Docusate
- Aprepitant
Summary
Aprepitant is an antiemetic drug used to prevent nausea and vomiting induced by chemotherapy and anesthesia. Aprepitant functions by blocking substance P from binding to the NK1 receptor in vomiting centers of the brainstem.
Key Points
- Aprepitant
- Mechanism:
- Blocks NK1 (neurokinin-1) receptors in brain
- Substance P antagonist
- Blocks NK1 (neurokinin-1) receptors in brain
- Clinical Use:
- Antiemetic for chemotherapy-induced nausea and vomiting
- Adverse Effects:
- Moderate inhibitor of CYP3A4
- Headache
- Constipation
- Mechanism: