Sevelamer
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Other Endocrine Pharm
- Thionamides (PTU vs Methimazole)
- ADH Antagonists (Conivaptan, Tolvaptan)
- Levothyroxine (T4) vs Liothyronine (T3)
- Demeclocycline
- Desmopressin
- Cinacalcet
- Sevelamer
Summary
Sevelamer is a drug that treats hyperphosphatemia by binding phosphate in the GI tract and preventing its absorption. GI upset is an important side effect of sevelamer.
Key Points
- Sevelamer
- Mechanism
- Nonabsorbable phosphate binder
- Taken orally, decreases phosphate absorption in GI tract
- Nonabsorbable phosphate binder
- Indications
- Hyperphosphatemia
- Classically used in chronic kidney failure (CKD)
- Kidneys are primary organ for phosphate excretion; CKD causes a toxic buildup of phosphate
- Hyperphosphatemia
- Adverse Effects
- Hypophosphatemia (obvious)
- GI Upset
- diarrhea, constipation, flatulence, dyspepsia
- contraindicated in bowel obstruction
- Mechanism