Sevelamer is a drug that treats hyperphosphatemia by binding phosphate in the GI tract and preventing its absorption. GI upset is an important side effect of sevelamer.

Key Points

  • Sevelamer
    • Mechanism
      • Nonabsorbable phosphate binder
        • Taken orally, decreases phosphate absorption in GI tract
    • Indications
      • Hyperphosphatemia
        • Classically used in chronic kidney failure (CKD)
        • Kidneys are primary organ for phosphate excretion; CKD causes a toxic buildup of phosphate
    • Adverse Effects
      • Hypophosphatemia (obvious)
      • GI Upset
        • diarrhea, constipation, flatulence, dyspepsia
        • contraindicated in bowel obstruction