Flutamide
7,838 views
Reproductive Pharm
- Leuprolide
- Anastrozole
- Estrogens
- Clomiphene
- Progestins
- Mifepristone
- Copper IUDs
- Danazol
- Terbutaline, Ritodrine
- Minoxidil
- Androgens (Testosterone, Methyltestosterone)
- Flutamide
- PDE-5 Inhibitors (Sildenafil, Vardenafil, Tadalafil)
- Finasteride
Summary
Flutamide is an anti-androgen drug that blocks the action of testosterone and DHT at androgen receptors. By reducing androgen signaling, flutamide may be useful in the treatment of testosterone or hormone-dependent prostate cancer. One of the side effects of taking flutamide is gynecomastia or the development of breasts in men.
Key Points
- Flutamide
- Mechanism
- Testosterone receptor blocker (anti-androgen)
- Nonsteroidal competitive antagonist at androgen receptors
- Blocks the stimulatory effects of testosterone and DHT
- Testosterone receptor blocker (anti-androgen)
- Indications
- Prostate cancer
- Prostate cancer is testosterone-dependent and can be treated with androgen deprivation
- Often coadministered with Leuprolide (long-acting GnRH agonist)
- Prostate cancer
- Side Effects
- Gynecomastia
- Mechanism