Flutamide
914
Summary
Flutamide is an anti-androgen drug that blocks the action of testosterone and DHT at androgen receptors. By reducing androgen signaling, flutamide may be useful in the treatment of testosterone or hormone-dependent prostate cancer. One of the side effects of taking flutamide is gynecomastia or the development of breasts in men.
Key Points
- Flutamide
- Mechanism
- Testosterone receptor blocker (anti-androgen)
- Nonsteroidal competitive antagonist at androgen receptors
- Blocks the stimulatory effects of testosterone and DHT
- Testosterone receptor blocker (anti-androgen)
- Indications
- Prostate cancer
- Prostate cancer is testosterone-dependent and can be treated with androgen deprivation
- Often coadministered with Leuprolide (long-acting GnRH agonist)
- Prostate cancer
- Side Effects
- Gynecomastia
- Mechanism