USMLE

Flutamide

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Reproductive Pharm
  1. Leuprolide
  2. Anastrozole
  3. Estrogens
  4. Clomiphene
  5. Progestins
  6. Mifepristone
  7. Copper IUDs
  8. Danazol
  9. Terbutaline, Ritodrine
  10. Minoxidil
  11. Androgens (Testosterone, Methyltestosterone)
  12. Flutamide
  13. PDE-5 Inhibitors (Sildenafil, Vardenafil, Tadalafil)
  14. Finasteride

Summary

Flutamide is an anti-androgen drug that blocks the action of testosterone and DHT at androgen receptors. By reducing androgen signaling, flutamide may be useful in the treatment of testosterone or hormone-dependent prostate cancer. One of the side effects of taking flutamide is gynecomastia or the development of breasts in men.

Key Points

  • Flutamide
    • Mechanism
      • Testosterone receptor blocker (anti-androgen)
        • Nonsteroidal competitive antagonist at androgen receptors
        • Blocks the stimulatory effects of testosterone and DHT
    • Indications
      • Prostate cancer
        • Prostate cancer is testosterone-dependent and can be treated with androgen deprivation
        • Often coadministered with Leuprolide (long-acting GnRH agonist)
    • Side Effects
      • Gynecomastia