V1 (Vasopressin) Receptors

Summary

V1 receptors are a type of G-protein coupled receptor activated by vasopressin, a hormone also known as antidiuretic hormone (ADH). V1 receptors are primarily located on vascular smooth muscle, and binding by vasopressin activates a Gq protein subunit, activating a signaling cascade that eventually leads to smooth muscle contraction and vasoconstriction. The resulting increase in systemic vascular resistance increases blood pressure.

Key Points

• V1 (Vasopressin) Receptors
  • GPCR that responds to Vasopressin / ADH
    • Activates a Gq subunit
  • Locations
    • Vascular smooth muscle
  • Actions
    • Vasoconstriction
      • Think: vaso- = vessel, -pressin = constriction
      • Increase in systemic vascular resistance increases blood pressure.