V1 (Vasopressin) Receptors

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Summary

V1 receptors are a type of G-protein coupled receptor activated by vasopressin, a hormone also known as antidiuretic hormone (ADH). V1 receptors are primarily located on vascular smooth muscle, and binding by vasopressin activates a Gq protein subunit, activating a signaling cascade that eventually leads to smooth muscle contraction and vasoconstriction. The resulting increase in systemic vascular resistance increases blood pressure.

Key Points

  • V1 (Vasopressin) Receptors
    • GPCR that responds to Vasopressin / ADH
      • Activates a Gq subunit
    • Locations
      • Vascular smooth muscle
    • Actions
      • Vasoconstriction
        • Think: vaso- = vessel, -pressin = constriction
        • Increase in systemic vascular resistance increases blood pressure.