V1 (Vasopressin) Receptors
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Summary
V1 receptors are a type of G-protein coupled receptor activated by vasopressin, a hormone also known as antidiuretic hormone (ADH). V1 receptors are primarily located on vascular smooth muscle, and binding by vasopressin activates a Gq protein subunit, activating a signaling cascade that eventually leads to smooth muscle contraction and vasoconstriction. The resulting increase in systemic vascular resistance increases blood pressure.
Key Points
- V1 (Vasopressin) Receptors
- GPCR that responds to Vasopressin / ADH
- Activates a Gq subunit
- Locations
- Vascular smooth muscle
- Actions
- Vasoconstriction
- Think: vaso- = vessel, -pressin = constriction
- Increase in systemic vascular resistance increases blood pressure.
- Vasoconstriction
- GPCR that responds to Vasopressin / ADH