USMLE

Aliskiren

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Cardiovascular Pharm
  1. Adenosine
  2. Magnesium
  3. Nitroprusside
  4. Nitrates
  5. Ivabradine
  6. Digoxin/Digitalis
  7. Class IA Antiarrhythmics
  8. Class IB Antiarrhythmics
  9. Class IC Antiarrhythmics
  10. Class II Antiarrhythmics
  11. Class III Antiarrhythmics - Amiodarone
  12. Class III Antiarrythmics - Sotalol
  13. Class III Antiarrhythmics - Ibutilide, Dofetilide
  14. Class IV Antiarrhythmics - Verapamil, Diltiazem
  15. HMG-CoA Reductase Inhibitors (Statins)
  16. Ezetimibe
  17. Fibrates
  18. PCSK9 Inhibitors (Alirocumab, Evolocumab)
  19. Fish Oil and Omega-3s
  20. Milrinone
  21. Aliskiren
  22. Hydralazine
  23. Ranolazine
  24. Sacubitril

Summary

Aliskiren is a direct renin inhibitor primarily used in the treatment of hypertension. Importantly, aliskiren is a teratogen, and should be avoided in pregnant women.

Key Points

  • Aliskiren
    • MOA
      • Direct renin inhibitor
        • preventing renin-mediated conversion of angiotensinogen to angiotensin I
    • Indications
      • Hypertension
        • Can be combined with other antihypertensive agents such as amlodipine or hctz
    • Side Effects
      • Teratogen
        • Contraindicated in pregnancy
      • Effects of renin inhibition
        • Hyperkalemia
        • Decreased GFR
        • Angioedema
        • Relatively contraindicated in patients already taking ACEI or ARBs; synergistic effects may induce hypotension
      • Non-specific: diarrhea, cough, nausea