Aliskiren
380
Summary
Aliskiren is a direct renin inhibitor primarily used in the treatment of hypertension. Importantly, aliskiren is a teratogen, and should be avoided in pregnant women.
Key Points
- Aliskiren
- MOA
- Direct renin inhibitor
- preventing renin-mediated conversion of angiotensinogen to angiotensin I
- Direct renin inhibitor
- Indications
- Hypertension
- Can be combined with other antihypertensive agents such as amlodipine or hctz
- Hypertension
- Side Effects
- Teratogen
- Contraindicated in pregnancy
- Effects of renin inhibition
- Hyperkalemia
- Decreased GFR
- Angioedema
- Relatively contraindicated in patients already taking ACEI or ARBs; synergistic effects may induce hypotension
- Non-specific: diarrhea, cough, nausea
- Teratogen
- MOA