USMLE

Osteosarcoma

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Misc
  1. Osteosarcoma
  2. McCune-Albright Syndrome
  3. Hexokinase vs Glucokinase
  4. COP I & II and Clathrin
  5. Kartagener Syndrome (Primary Ciliary Dyskinesia)
  6. Familial Adenomatous Polyposis (FAP)
  7. Peutz-Jeghers Syndrome
  8. Cystic Fibrosis Overview
  9. Cystic Fibrosis Complications
  10. Medicare vs Medicaid
  11. Duchenne and Becker Muscular Dystrophy
  12. Yolk Sac Tumor
  13. Rett Syndrome
  14. Fragile X Syndrome
  15. Whipple's Disease
  16. Osteoid Osteoma vs Osteoblastoma
  17. T1 vs T2 MRIs

Summary

Osteosarcoma is an aggressive bone cancer of osteoblasts, or the cells that lay down new bone.  Osteosarcoma has a bimodal distribution: primary osteosarcoma is usually seen in young adults, while secondary osteosarcomas are seen in the elderly. 

Osteosarcoma generally occurs in the metaphysis of long bones, and especially near the knee in the distal femur or proximal tibia. Imaging findings include Codman’s triangle or a sunburst pattern on X-ray. Finally, osteosarcoma is associated with familial retinoblastoma and Li-Fraumeni syndrome, both cancer syndromes that are highly associated with bone cancers.