Medicine & USMLE

Osteosarcoma

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Misc
  1. Osteosarcoma
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Summary

Osteosarcoma is an aggressive bone cancer of osteoblasts, or the cells that lay down new bone.  Osteosarcoma has a bimodal distribution: primary osteosarcoma is usually seen in young adults, while secondary osteosarcomas are seen in the elderly. 

Osteosarcoma generally occurs in the metaphysis of long bones, and especially near the knee in the distal femur or proximal tibia. Imaging findings include Codman’s triangle or a sunburst pattern on X-ray. Finally, osteosarcoma is associated with familial retinoblastoma and Li-Fraumeni syndrome, both cancer syndromes that are highly associated with bone cancers.