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Pharmacology

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Anticholinergics

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Oxybutynin Solifenacin Tolterodine

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Summary

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Key Points

  • Oxybutynin, Solifenacin, Tolterodine
    • Mechanism
      • Muscarinic Antagonist
    • Clinical Uses
      • Reduce bladder spasms and urge urinary incontinence (overactive bladder)
        • Due to blockade of M3 receptors on bladder detrusor muscle (contractor muscle)
    • Adverse effects
      • Avoid in elderly patients due to delirium risk (Beer’s Criteria)