Donepezil Rivastigmine and Galantamine
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Cholinomimetics
- Bethanechol
- Carbachol
- Methacholine
- Pilocarpine
- Donepezil Rivastigmine and Galantamine
- Edrophonium
- Neostigmine
- Physostigmine
- Pyridostigmine
Summary
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Key Points
- Donepezil, Rivastigmine, Galantamine
- Mechanism
- Acetylcholinesterase inhibitor
- Increases ACh levels in the brain by preventing its breakdown
- Thought to increase M1 signaling in brain
- Acetylcholinesterase inhibitor
- Clinical Use
- Alzheimer Disease
- Decreased acetylcholine levels are a common feature in Alzheimer's disease
- Drugs improve cognition, behavior, and functioning in activities of daily living
- Not curative; cannot reverse neurodegeneration
- Alzheimer Disease
- Adverse Effects
- Nausea, dizziness, insomnia
- Mechanism