Medicine & USMLE

Donepezil Rivastigmine and Galantamine

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Cholinomimetics
  1. Bethanechol
  2. Carbachol
  3. Methacholine
  4. Pilocarpine
  5. Donepezil Rivastigmine and Galantamine
  6. Edrophonium
  7. Neostigmine
  8. Physostigmine
  9. Pyridostigmine

Summary

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Key Points

  • Donepezil, Rivastigmine, Galantamine
    • Mechanism
      • Acetylcholinesterase inhibitor
        • Increases ACh levels in the brain by preventing its breakdown
        • Thought to increase M1 signaling in brain
    • Clinical Use
      • Alzheimer Disease
        • Decreased acetylcholine levels are a common feature in Alzheimer's disease
        • Drugs improve cognition, behavior, and functioning in activities of daily living
        • Not curative; cannot reverse neurodegeneration
    • Adverse Effects
      • Nausea, dizziness, insomnia