Medicine & USMLE

Donepezil Rivastigmine and Galantamine

9,178 views
Cholinomimetics
  1. Bethanechol
  2. Carbachol
  3. Methacholine
  4. Pilocarpine
  5. Donepezil Rivastigmine and Galantamine
  6. Edrophonium
  7. Neostigmine
  8. Physostigmine
  9. Pyridostigmine

Summary

Coming soon...

Key Points

  • Donepezil, Rivastigmine, Galantamine
    • Mechanism
      • Acetylcholinesterase inhibitor
        • Increases ACh levels in the brain by preventing its breakdown
        • Thought to increase M1 signaling in brain
    • Clinical Use
      • Alzheimer Disease
        • Decreased acetylcholine levels are a common feature in Alzheimer's disease
        • Drugs improve cognition, behavior, and functioning in activities of daily living
        • Not curative; cannot reverse neurodegeneration
    • Adverse Effects
      • Nausea, dizziness, insomnia