Medicine & USMLE


Other Neuro Pharm
  1. Ramelteon
  2. Triptans
  3. Benzodiazepines - Function
  4. Zolpidem Zaleplon Eszopiclone
  5. Suvorexant
  6. Bromocriptine (Ergot Dopamine Agonists)
  7. Pramipexole, Ropinirole
  8. Amantadine
  9. Levodopa, Carbidopa
  10. Entacapone, Tolcapone
  11. Selegiline and Rasagiline
  12. Benztropine, Trihexyphenidyl
  13. Tetrabenazine
  14. Baclofen
  15. Memantine
  16. Riluzole
  17. Full Opioid Agonists
  18. Partial Opioid Agonists
  19. Dextromethorphan
  20. Tramadol
  21. Naloxone
  22. Naltrexone


Memantine is a drug that is used to treat Alzheimer dementia. It works by antagonizing or blocking NMDA receptors in neurons, which reduces excitotoxicity thought to contribute to the disease.  They are used to treat moderate to severe Alzheimer dementia, often in combination with acetylcholinesterase inhibitors. Use of memantine may lead to a few side effects, including dizziness, confusion, and hallucinations.

Key Points

  • Memantine
    • Mechanism
      • NMDA receptor antagonist
        • NDMA (N-methyl-D-aspartate) signaling may cause excitotoxicity (mediated by Ca2+)
        • Believed to decrease intracellular calcium accumulation to aid in the prevention of excitotoxic neuronal damage
    • Clinical Use
      • Alzheimer disease
        • Used for moderate to advanced dementia
    • Adverse Effects
      • Dizziness, confusion, hallucination