Medicine & USMLE

Anaplasma vs. Ehrlichia

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Bacteria - Gram Negative
  1. Neisseria spp: Overview
  2. Neisseria gonorrhoeae
  3. Neisseria meningitidis
  4. Haemophilus influenzae
  5. Bordetella pertussis
  6. Brucella
  7. Legionella pneumophila
  8. Pseudomonas aeruginosa: Overview
  9. Pseudomonas aeruginosa: Disease
  10. Salmonella Overview
  11. Salmonella typhi
  12. Salmonella enteritidis
  13. Shigella
  14. Yersinia enterocolitica
  15. Escherichia coli: Overview
  16. Enterohemorrhagic E. Coli (EHEC)
  17. Enterotoxigenic E. Coli (ETEC)
  18. Klebsiella pneumoniae
  19. Campylobacter jejuni
  20. Vibrio spp.
  21. Helicobacter pylori
  22. Borrelia burgdorferi (Lyme Disease)
  23. Leptospira interrogans
  24. Treponema pallidum: Overview
  25. Treponema pallidum: Diagnosis
  26. Congenital syphilis
  27. Chlamydia: Overview
  28. Chlamydia trachomatis
  29. Chlamydia pneumoniae vs. psittaci
  30. Rickettsia rickettsii
  31. Rickettsia typhi vs. prowazekii
  32. Anaplasma vs. Ehrlichia
  33. Coxiella burnetii (Q fever)

Anaplasma vs. Ehrlichia 

  • Characteristics
    • Obligate intracellular
      • Grow inside vacuoles in human and animal WBCs
  • Vectors
    • Tick
      • Anaplasma: Ixodes tick
      • Ehrlichia: Lone Star tick
  • Presentation
    • Non-specific flu-like illness (fever, chills, malaise, myalgia, headache)
    • Ehrlichia: Rash may occur
      • Contrast vs. Anaplasma, which does not present with rash
  • Histology
    • morulae (mulberry-like inclusions) in cytoplasm 
      • Anaplasma: grows inside granulocytes (neutrophils)
      • Ehrlichia: grows inside monocytes (macrophages)
  • Treatment 
    • Doxycycline is first-line
      • Rifampin or chloramphenicol are second line when tetracyclines are not tolerated