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Anaplasma vs. Ehrlichia

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Anaplasma vs. Ehrlichia 

  • Characteristics
    • Obligate intracellular
      • Grow inside vacuoles in human and animal WBCs
  • Vectors
    • Tick
      • Anaplasma: Ixodes tick
      • Ehrlichia: Lone Star tick
  • Presentation
    • Non-specific flu-like illness (fever, chills, malaise, myalgia, headache)
    • Ehrlichia: Rash may occur
      • Contrast vs. Anaplasma, which does not present with rash
  • Histology
    • morulae (mulberry-like inclusions) in cytoplasm 
      • Anaplasma: grows inside granulocytes (neutrophils)
      • Ehrlichia: grows inside monocytes (macrophages)
  • Treatment 
    • Doxycycline is first-line
      • Rifampin or chloramphenicol are second line when tetracyclines are not tolerated