Enterohemorrhagic E. Coli (EHEC)
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Bacteria - Gram Negative
- Neisseria spp: Overview
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Haemophilus influenzae
- Bordetella pertussis
- Brucella
- Legionella pneumophila
- Pseudomonas aeruginosa: Overview
- Pseudomonas aeruginosa: Disease
- Salmonella Overview
- Salmonella typhi
- Salmonella enteritidis
- Shigella
- Yersinia enterocolitica
- Escherichia coli: Overview
- Enterohemorrhagic E. Coli (EHEC)
- Enterotoxigenic E. Coli (ETEC)
- Klebsiella pneumoniae
- Campylobacter jejuni
- Vibrio spp.
- Helicobacter pylori
- Borrelia burgdorferi (Lyme Disease)
- Leptospira interrogans
- Treponema pallidum: Overview
- Treponema pallidum: Diagnosis
- Congenital syphilis
- Chlamydia: Overview
- Chlamydia trachomatis
- Chlamydia pneumoniae vs. psittaci
- Rickettsia rickettsii
- Rickettsia typhi vs. prowazekii
- Anaplasma vs. Ehrlichia
- Coxiella burnetii (Q fever)
- Enterohemorrhagic E. coli (EHEC)
- Virulence Factors
- O157:H7 is most common EHEC serotype in US
- Produces Shiga-like toxin (verotoxin)
- inactivates 60s ribosomal subunit, stopping protein production and leading to cell death
- Major mediator of pathogenicity; toxin-mediated enterocyte death and intestinal hemorrhage
- Similar to the mechanism of shiga toxin in Shigella spp.
- Contrast vs. Shigella, where toxin plays minor role in pathogenesis
- Transmission
- Ingested via undercooked meat (beef)
- unpasteurized milk, contaminated water are also sources
- Ingested via undercooked meat (beef)
- Presentation
- Bloody Diarrhea
- May be complicated by Hemolytic-uremic syndrome (HUS)
- Triad of hemolytic anemia, thrombocytopenia, and kidney injury
- Virulence Factors