Pseudomonas aeruginosa: Disease
6,613 views
Bacteria - Gram Negative
- Neisseria spp: Overview
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Haemophilus influenzae
- Bordetella pertussis
- Brucella
- Legionella pneumophila
- Pseudomonas aeruginosa: Overview
- Pseudomonas aeruginosa: Disease
- Salmonella Overview
- Salmonella typhi
- Salmonella enteritidis
- Shigella
- Yersinia enterocolitica
- Escherichia coli: Overview
- Enterohemorrhagic E. Coli (EHEC)
- Enterotoxigenic E. Coli (ETEC)
- Klebsiella pneumoniae
- Campylobacter jejuni
- Vibrio spp.
- Helicobacter pylori
- Borrelia burgdorferi (Lyme Disease)
- Leptospira interrogans
- Treponema pallidum: Overview
- Treponema pallidum: Diagnosis
- Congenital syphilis
- Chlamydia: Overview
- Chlamydia trachomatis
- Chlamydia pneumoniae vs. psittaci
- Rickettsia rickettsii
- Rickettsia typhi vs. prowazekii
- Anaplasma vs. Ehrlichia
- Coxiella burnetii (Q fever)
Pseudomonas aeruginosa disease
- Presentation
- 4 main groups of people affected
- Exposure to contaminated water of hot tubs/pools
- Malignant otitis externa (MOE)
- Severe infection of outer ear tissue exposed to water
- Presents with severe pain and drainage
- Untreated conditions can progress to osteomyelitis of skull
- Rash (“hot tub folliculitis”)
- infection of hair follicles exposed to contaminated water
- Itchy, papulopustular rash over trunk and extremities
- Malignant otitis externa (MOE)
- Cystic Fibrosis
- Pneumonia
- Increased viscosity of airway in CF mucus impairs mucociliary escalator to clear bacteria
- Recurrent respiratory infections with P. aeruginosa, diarrhea/steatorrhea, and failure to thrive are classic
- Pneumonia
- Immunocompromised patients
- Ecthyma gangrenosum
- Rapidly progressive necrotic lesion that is manifestation of Pseudomonas bacteremia
- Exotoxins and invasion of bacteria destroy blood vessels and surrounding tissue, causing necrosis
- Often seen in patients with low absolute neutrophil count (e.g. cancer post-chemo, bone marrow transplant)
- Ecthyma gangrenosum
- Indwelling (Foley) urinary catheter
- UTIs (urinary tract infection)
- Exposure to contaminated water of hot tubs/pools
- Osteomyelitis may be seen in IV drug users/diabetic patients
- Corneal ulcers/keratitis may be seen in contact lens wearers
- Wound infection may be seen in burn victims
- 4 main groups of people affected
- Treatment
- Piperacillin, ticarcillin
- Only some extended spectrum penicillins are effective
- Ceftazidime, cefepime
- Note: ceftriaxone is NOT effective
- Fluoroquinolones (e.g. ciprofloxacin, levofloxacin)
- Carbapenems (e.g. meropenem, imipenem)
- Aminoglycosides
- Monobactams
- Polymyxins (e.g. polymyxin B, colistin)
- Piperacillin, ticarcillin