USMLE

Brucella

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Bacteria - Gram Negative
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Brucella 

  • Characteristics
    • Gram negative coccobacillus 
    • Facultative intracellular
  • Transmitted via ingestion of contaminated animal products (e.g. unpasteurized milk)
    • May also be transmitted by direct contact with infected sheep/goats 
    • Survives in macrophages in the reticuloendothelial system
    • Can form non-caseating granulomas
  • Presentation
    • Undulant fever
      • Night sweats may be seen
    • Lymphadenopathy
    • Hepatosplenomegaly
    • Arthralgia
  • Diagnosis
    • Blood or bone marrow culture
  • Treatment
    • Doxycycline and rifampin 
    • Streptomycin 
      •  indicated for relapse of disease