Neisseria spp: Overview
6,045 views
Bacteria - Gram Negative
- Neisseria spp: Overview
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Haemophilus influenzae
- Bordetella pertussis
- Brucella
- Legionella pneumophila
- Pseudomonas aeruginosa: Overview
- Pseudomonas aeruginosa: Disease
- Salmonella Overview
- Salmonella typhi
- Salmonella enteritidis
- Shigella
- Yersinia enterocolitica
- Escherichia coli: Overview
- Enterohemorrhagic E. Coli (EHEC)
- Enterotoxigenic E. Coli (ETEC)
- Klebsiella pneumoniae
- Campylobacter jejuni
- Vibrio spp.
- Helicobacter pylori
- Borrelia burgdorferi (Lyme Disease)
- Leptospira interrogans
- Treponema pallidum: Overview
- Treponema pallidum: Diagnosis
- Congenital syphilis
- Chlamydia: Overview
- Chlamydia trachomatis
- Chlamydia pneumoniae vs. psittaci
- Rickettsia rickettsii
- Rickettsia typhi vs. prowazekii
- Anaplasma vs. Ehrlichia
- Coxiella burnetii (Q fever)
Neisseria spp.
- Includes:
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Gram-negative diplococci
- Contain lipooligosaccharides (LOS) with strong endotoxin activity
- Facultatively intracellular
- Often visualized within epithelial cells
- Grows on Thayer-Martin agar
- Selective chocolate (heated-blood) agar-based medium containing the antibiotics vancomycin, colistin, nystatin and trimethoprim
- Prevents growth of microbes other than Neisseria
- Produce IgA protease
- Cleave IgA at hinge region, impairing its function at mucosal surfaces
- Improves mucosal adherence
- Increased risk with terminal complement deficiency (C5-C9)
- Inability to generate membrane attack complex (MAC) leads to poor clearance of bacteria
- Pili
- Hair-like proteins that facilitates attachment to mucosal surfaces
- Nasopharynx for N. meningitidis, vaginal/urethral for gonorrhoea
- No vaccine due to antigenic variation of pilus proteins
- Hair-like proteins that facilitates attachment to mucosal surfaces
- Disseminated infections present with petechial skin rash
- Due to small-vessel vasculitis