Staph saprophyticus
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- Staphylococcus saprophyticus
- Gram + cocci in clusters
- Catalase +
- First test to differentiate staph vs. strep (catalase negative)
- Coagulase –
- Second test to differentiate from staph aureus (coagulase positive)
- Novobiocin resistant
- Third test to differentiate vs. staph epidermidis (novobiocin-sensitive), by exposure to the antibiotic novobiocin
- Urease positive
- Found to be a virulence factor in the development of UTIs
- Cleavage of urea into ammonia and carbon dioxide may produce an environment more friendly to growth
- Normal flora of female genital tract and perineum
- Causes UTls in sexually active women
- Second most common cause, after E. coli
- Presents with dysuria, urinary frequency/urgency, suprapubic pain
- Microorganisms adhere to uroepithelial cells
- Treatment
- Trimethoprim-sulfamethoxazole
- Nitrofurantoin