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Methicillin-Resistant Staph aureus (MRSA)

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MRSA (methicillin-resistant S. aureus)

  • Resistance to beta-lactam antibiotics (e.g. methicillin)
  • Important cause of serious nosocomial and community-acquired infections
  • altered penicillin-binding protein target site
    • Alterations in structure of penicillin-binding proteins (PBP), enzymes involved in bacterial cell wall synthesis
    • mecA gene from staphylococcal chromosomal cassette involved in penicillin resistance
  • Treatment 
    • Vancomycin (drug of choice) 
    • Linezolid
      • Can be used for vancomycin-related S. aureus (VRSA)